Inflammatory markers of bloodserum as an early predictor of chronic diseases in the rural population of Sachkhere district in Georgia

Abstract

To identify the molecular correlates of non-communicable chronic disease risk in the territory of Upper Imereti. Practically healthy residents of the Sachkhere district were examined. In the blood serum samples of patients, the cytokines (IL-1α, IL-1β, IL-12, TNF-α, IL-6) and NOx content, as well as the total antioxidant activity of the non-enzymatic system (TAA) were determined. Study results show, that in Sareki inhabitant’s blood serum levels of the IL-6, and NO increased (p=0.004, p=0.05), levels of the IL-1α tended to increase (p=0.057) compared to the corresponding values of the Chorvila inhabitants; in Chorvila inhabitants’ indicators of blood serum TAA were lower than in Sairkhe and Sareki (p=0.001, p=0.045). The statistically significant differences in the levels of the IL-1β, IL12, and TNF-α in the blood serum of the inhabitants of Sachkhere district villages were not revealed. The alterations of the indicators of immune and oxidative status in the practically healthy populations of the Sachkhere district villages toward pro-inflammatory, and early revealed associations between population morbidity and TAA values allow us to suggest considering immune (IL6, IL-1α) and redox status deviations as markers of predisposition to chronic diseases. It should also be noted that, since each indicator belongs to the class of pleiotropic markers, only their complex can be considered as an early predictor of risk.