Myocardial Ischemia and Diabetes Mellitus. Approaches and Recommendation
The outlook epidemiological auguring an increase considerable the number of subjects with diabetes and cardiological problem during diabetes, and the recent progress registered in the explorations and the treatment of coronary are necessary for to continue research. Since long been recognized as a factor of risk vascular age, the diabetes can be regarded as a genuine vascular disease in because of the frequency and in the severity. The share growing, observed and expected, of the population of diabetics, whose prognosis life is dominated by the complication’s coronary up the diabetes mellitus among the priorities of health public in France. The specifi c features of diabetic coronary artery disease, marked by the often-insidious nature of its development, place silent myocardial ischemia (IMS) and possible atheromatous involvement of the epicardial coronary artery trunks at the center of the diagnostic and therapeutic approach. The progress, drug and instrumentals, the treatment of the inadequacy coronary lead naturally to reconsider the treatment, and therefore the screening early to IMS in the aim of reducing the morbidity and the mortality heart of patients with diabetes.
Copyright (c) 2021 Puel Le Pr Jacques, Paul Valensi, Gerald Vanzetto, Vague Lassmann-Vague, Jean-Luc Monin, Philippe Moulin, Cr Ziccarelli, Herve Mayaudon, Michel Ovize, Sophia Bernard, Eric Van Belle, Serge Halimi (Author) https://creativecommons.org/licenses/by-sa/4.0/
Rheological Parameters in Patients with Brain Infarct During COVID-19
In the description of the analytical clinical data of the patients with COVID-19 from difference country. In article shows detailed description of the rheological situation in patients with neuropathic during COVID-19. This data was compared with results of rheological study in analogical disease group patients without COVID-19. The article describes the effect of various anticoagulants on blood rheology, also describing protocols. In vivo, in vitro experiments, that studied a range of rheological parameters different anticoagulants. Measurement of RBC aggregation, RBC deformities, plasma viscosity were study with innovative technologies, quantitative methods. The work presents a scientifi c focus, after deep and increase research area is able to transport the newest conclusion to the clinical practice to treatment management of COVID-19.
Copyright (c) 2021 Nadia Antonova, Farber Paulo Luiz, Carlota Saldanha, Ana Santos Silva-Herdade (Author) https://creativecommons.org/licenses/by-sa/4.0/
Details of Laboratory Work for Medical Students
In the modern world of pandemics, a special place is occupied by the problems of education in the fi eld of medicine. In developed countries, medical education remains combined. Practical training of students in the laboratories of the university is very important. The article describes a biochemistry laboratory class protocol. This protocol is described in order to create an opportunity for students to apply by doing the theoretical concepts underlying biomolecules and vesicles properties, together with the principles of centrifugation and colorimetric methodologies. The aims, objectives, methodology of teaching/learning, and assessment for this laboratory class are indicated. The proposed protocol for a laboratory class described us creates the opportunity for undergraduate students to perform experiments, to reason, and to discuss some related biochemical concepts, namely protein characterization and properties of specifi c staining reactions; enzyme quantifi cation by enzymatic reaction; composition and biochemical properties of exovesicles; amphiphilic biomolecules properties; and principles and applications of centrifugation methods. This work was supported by Portuguese Ministry of Science and Higher Education (MCES).
Copyright (c) 2021 Carlota Saldanha, Nuno Santos, Martins Silva Jeferson Pereira (Author) https://creativecommons.org/licenses/by-sa/4.0/
Relevance Methodto Structure of Orthosis
There are many problems when treatment is needed. Such diseases occur in young and old people. The orthosis and their development have lot of problems. One way to solve this problem is to defi ne and apply standard rules and procedures throughout the development process. We show in this work is to develop a methodology to structure the orthosis design process. A case study was used to validate the proposed methodology. It was applied to the development of an orthosis to treat a camptocormia – bent spine syndrome. This disorder is characterized by the anterofl exion of the trunk and especially affects elderly people and young non-health people with difference disease.
Copyright (c) 2021 Michel Mesnard (Author) https://creativecommons.org/licenses/by-sa/4.0/
From Full-Time Traditional Education to a Distant Form Due the Pandemic Caused by COVID-19
The article presents data on the prerequisites of different countries on the issue of distance education. In the article the percentage valuation of the distance form of education in relation to the full-time traditional form was shown before the pandemic caused by the new coronavirus and after. In connection with the COVID-19 pandemic, a change in these proportions occurred due to an increase in the partial part of distance learning against the background of a suspended full-time traditional education. In a number of countries, distance learning has become the only one, absorbing all other educational approaches and systems. This provided the education system with special signifi cance and attention from state structures and the government. The relevance of the work is caused by the fundamental nature of the issue of education, as such in general and specifi cally now, in a pandemic situation. Against the background of WHO recommendations on universal social distance and strict restrictions on mass events, which are an integral part of full-time traditional education, the urgency of the emergency transition from full-time traditional education to distance learning is especially great. The relevance of the issue is increasing due to the uncertainty caused by the expectation of the second wave of coronavirus, which is expected in October and coincides with the beginning of the fi rst semester of the 2020/2021 academic year.
Copyright (c) 2021 Maia Mantskava, Carlota Saldanha (Author) https://creativecommons.org/licenses/by-sa/4.0/
Investigation of Microcirculatory in Resistive Arteries
Тhe article shows the physiological signifi cance of resistive arteries in relation to blood fl ow. The article describes a new non-invasive method for assessing the functional state of resistive arteries, which indicates the resistance of resistive arteries. Microcirculation coeffi cient – resistance of resistive arteries is an easyto- use diagnostic method for assessing circulatory problems. The article shows new normative indicators of the microcirculation index in young healthy men. And also shows the rheological indicators for the same group.
Copyright (c) 2021 Iuri Niashin (Author) https://creativecommons.org/licenses/by-sa/4.0/
Some Aspects of Research on Interpersonal Relationships and Motivations of Healthcare Professionals
The modern theory and practice of medicine, as well as a number of other edological (helping) disciplines and practices, have been supplemented by a very productive area called “evidence-based medicine”. Its occurrence is associated with a large number of bioethical problems, including the problem of the confl ict of interests between a doctor and a patient. A confl ict of interest is born as a result of confl icting motives of relationships and interactions between the activities of a medical worker. The contradiction of interests and motives of activity is manifested in the phenomena of professional psychological burnout and professional deformations. The article highlights the main motives contributing to the confl ict of interest, as well as ways of preventing and correcting confl icts of interest in connection with the implementation of these motives. Among the main motives, one can name the motives associated with the unresolved personal and interpersonal problems of a specialist: his need for power and control, for confi rmation and for belonging.
Copyright (c) 2021 Maria Arpentieva (Author) https://creativecommons.org/licenses/by-sa/4.0/
Hepatoprotective Therapy for Disease and Diabetes
Our work is devoted to the treatment of non-alcoholic fatty liver disease as a complication in patients with complex cardiovascular pathology and type 2 diabetes mellitus. The data of the study of the effect of the drug Hepa-Merz® on the functional state of the liver, endothelium, rheological properties of blood, the state of capillary blood fl ow, markers of endotoxicosis and clinical state in this category of patients are presented. The results obtained confi rm the possibility of using the drug Hepa-Merz® for liver functional disorders in patients with cardiovascular diseases and complex type 2 diabetes mellitus.
Copyright (c) 2021 Viktoria Lishnevska (Author) https://creativecommons.org/licenses/by-sa/4.0/
Programmatic Management of Tuberculosis during COVID-19 Pandemic in Georgia
The article reveals the real problems caused by the pandemic associated with the new coronavirus. The problems affected the implementation of the National Tuberculosis Program. It is important for National TB Programs to put all efforts in active case detection, treatment adherence and preventive treatment implementation in response to COVID-19 impact on TB epidemics.
Copyright (c) 2021 Zaza Avaliani, Nino Lomtadze (Author) https://creativecommons.org/licenses/by-sa/4.0/
Impact of Training on Perception in Dissociated Cortical Culture Neural Networks
The way we recall events has an impact on how we perceive them. A good example of this is visual illusion. Can memorized stimuli infl uence the acquisition of a variety of stimuli in tiny neural networks? To answer this question, we used dissociated cortical culture (DCC) grown on a multielectrode array. This in vivo-like in vitro system allows tracking and assessing structural and functional refi nement, as well as the ability for information acquisition, processing, and coding in neural networks. A range of electric stimuli were used to simulate sensory inputs and to train DCC neural circuits. Single, paired-pulse (PP, 20ms ISI) 300mV stimuli at 5, 10, 20, 50, and 100Hz for 1s were delivered in a random time interval. During the analyses, the pre-training, training and testing phases were compared. The data revealed that registered channels increased activity in response to one of the stimulus types while responding less effectively to others. Single, 5Hz, and notably PP stimuli were the favored paradigms. The training phase frequently showed a progressive increase in activity level, with short burst prevalence. However, repetition of the preferred stimuli enhanced the occurrence of both tonic and burst evoked responses with prolonged duration throughout the testing phase. The data demonstrate that even such a tiny network of neurons as we have in DCC is capable for selection of the sensory inputs according to previously memorized information and at their most basic levels they are effi - cient of performing some functions that are typically attributed to higher neural structures.
Copyright (c) 2021 Duda Kvitsiani, Khatia Nadirashvili, Tatia Tsmindashvili, Nino Nebieridze, Cezar Goletiani (Author) https://creativecommons.org/licenses/by-sa/4.0/
The Portrayal of Diseases in the Novels of Zoe Heller and Joanne Harris
The article zeroes in on the vision that diseases, alienation and grotesqueness are inseparable. It suggests that mental and physical disorders contribute to realizing the scale of alienation and grotesqueness inside and outside the characters. The current research shows the way diseases determine human interaction. It elucidates the characters’ paradigm shift in their understanding of themselves and the world after a disease has entered their lives. The presence of symptoms, syndromes and traumas in the novels presupposes that society is far from being balanced. The article also discloses the overlap of literary discourse with medical discourse.
Copyright (c) 2021 Antonina Bulyna (Author) https://creativecommons.org/licenses/by-sa/4.0/
Experimental Studies of Blood Cells and Intensity of Blood Flow
We have carried out several in vitro experiments for study of erythrocyte aggregation and leukocyte aggregation. After discussing the results, it turned out that it turned out that the change in aggregation forms the blood fl ow to a greater extent than the aggregation of leukocytes. An increase in aggregation was caused by adding Dextran 500 to the tubes. This is a proven method for increasing aggregation intensity. It turned out that the aggregation of erythrocytes is a stable value compared to the aggregation of leukocytes. It also turned out that the aggregation of erythrocytes changes immediately after the addition of Dextran 500, but not signifi cantly. Research in this direction must continue to receive date how informative the aggregation of erythrocytes and the aggregation of leukocytes are in case of difference diseases.
Copyright (c) 2021 Afshin Zardoshtian (Author) https://creativecommons.org/licenses/by-sa/4.0/
New Parameters of Hemostasis, some of their Research Results during Pregnancy
The article presents up-to-date information about the hemostasis system is a biological system that ensures the preservation of the liquid state of the blood, maintaining the integrity of the walls of blood vessels, preventing and stopping bleeding from the latter by thrombosis. Hemostasis is implemented mainly by three interacting functional and structural components: the walls of blood vessels (primarily intima), blood cells (platelets, erythrocytes, etc.) and plasma enzyme systems (coagulation, fi brinolytic, kallikrein-kinin, etc.). The article presents data from original studies of 20 women with their fi rst pregnancy between the ages of 25 and 28 (the gestation period was 18 to 20 weeks). And 10 non-pregnant women (control group). We studied the aggregation of enterocytes and to study the aggregation of platelet aggregation (Rheoscan apparatus). Further, by transforming the data with the technical analysis program (Tas-Plus apparatus), we calculated the platelet and erythrocyte aggregation indexes (PAI and EAI). The research was conducted in accordance with the Declaration of Helsinki. Pregnant and healthy control women were notifi ed of the study. We have received informational consent from them. Our statistical data showed that the aggregation of erythrocytes (EAI) is increased in comparison with the norm by 15% (*), the aggregation of platelets (PAI) is increased in comparison with the norm by 25% (*).
Copyright (c) 2021 Carlota Saldanha (Author) https://creativecommons.org/licenses/by-sa/4.0/
Forming New Preventive Approaches in Sports Medicine
Sports training, physical education and health and fi tness work is a process in the fi rst the turn is socio-pedagogical, which determines the leading role of the trainer and teacher in it. However, the object of this process is a person with all the complexity of his psyche, body functions and relationships with the environment. Due to this the effectiveness of the process largely depends on the correspondence of the means and methods used to the state health, functionality, age and individual characteristics of each person. In modern conditions, when the health of the population, fi rst of all, the younger generation, has signifi cantly deteriorated, this is of particular importance.
Copyright (c) 2021 Brun Jean Frederic (Author) https://creativecommons.org/licenses/by-sa/4.0/
The latest approach in planningl aparoscopic antireflux surgery for the treatment of gastroesophageal reflux disease in Georgia by single surgical team
Gastroesophageal reflfl ux disease (GERD) is one of the most common pathologies of the gastrointestinal tract detected in adults. The implementation of a differential approach in diagnostics is possible through the complex simultaneous application of several examination methods, such as endoscopic and radiological. Standard treatment includes medical and laparoscopic methods of solving problems. The success of laparoscopic surgery depends on many factors. For example, from the knowledge, skill, experience of a group of surgeons. As an innovation for the success of surgical treatment of the patient and his personalization, we proposed additional scientififi c and experimental approaches, such as modeling and determining the rheology of the masses.
Copyright (c) 2022 David, Otar Kepuladze, Maia Mantskava, Nana Momtselidze, Giorgi Kuchava (Author) https://creativecommons.org/licenses/by-sa/4.0/
The role of computed tomography in a diagnostic approach to cystic lung diseases and their differential diagnosis
In everyday routine, lung cysts are commonly seen in Computed Tomography, as far as many different conditions and diseases are associated with air cysts. Thus, correct diagnosis of cystic lung diseases, which show a wide spectrum, is a challenge for radiologists. For diagnosis and differential diagnosis, fifi rst of all, cysts should be distinguished from such other air fifi lled lesions, like cavities, bullae, pneumatocele, emphysema, honeycombing and cystic bronchiectasis. Second, cysts can be categorized as single/localized versus multiple/diffuse. Solitary/localized cysts include incidental cysts, congenital cystic diseases and cystic cancers. Multiple/diffuse cysts can be further categorized according to the presence or absence of associated radiologic fifi ndings. Multiple/diffuse cysts without associated fifi ndings include lymphangioleiomyomatosis and Birt-Hogg-Dubé syndrome. Multiple/diffuse cysts may be associated with ground-glass opacity or small nodules. Multiple/diffuse cysts with nodules include Langerhans cell histiocytosis, cystic metastasis and amyloidosis. Multiple/diffuse cysts with ground-glass opacity include pneumocystis pneumonia, desquamative interstitial pneumonia and lymphocytic interstitial pneumonia. The stepwise radiologic diagnostic approach can be helpful in reaching a correct diagnosis for various cystic lung diseases.
Copyright (c) 2022 Nino Gabashvili, Zaza Avaliani (Author) https://creativecommons.org/licenses/by-sa/4.0/
Alteration of immune status during treatment with β-blockers in patients with essential hypertension
The balance of cytokines (IL-2, IL-10, IF-γ) in patients with essential hypertension before and after treatment with β-blockers was studied. 20 patients aged 45-65 years and diagnosed with essential hypertension (12 women, 8 men) were investigated. For the treatment of hypertension, patients received second-generation beta-selective β-blockers Egilok and Betalok Zok, and third-generation β-blocker Nebilet for one month. Patients performed their blood pressure measurements daily in the morning during I month. The content of interleukins (IL-2, IL-10, IF-γ) in the blood by the immune enzymatic ELISA method on a semi-automatic reader Stat Fax 3200 with RayBio, (USA) reagent was measured. The results of our studies show an increase in the level of CD4+ (IL-2) cytokines in the blood of the studied hypertensive patients, which coincides with the literature data on the important role of CD4+ pro-inflfl ammatory cytokines in the pathogenesis of hypertension. After 1 month of treatment with β-blockers, the patient’s arterial pressure and IL-2 level content in the blood decreased. These data indicate the important role of inflfl ammation in the pathogenesis of hypertension and the anti-inflfl ammatory effects of β-brokers, used in the treatment of hypertension.
Copyright (c) 2022 Tamar Sharashenidze, Maka Buleishvili, Marina Tsimakuridze, Magda Tortladze, Tamar Sanikidze (Author) https://creativecommons.org/licenses/by-sa/4.0/
Diagnosis and treatment of Idiopathic Pulmonary Fibrosis (IPF) has been greatly inflfl uenced by the COVID-19 pandemic. Not only has it impacted the prognosis of the Idiopathic Pulmonary Fibrosis, but also the approach to treating these patients. The aim of this study was to evaluate our patient who got infected with COVID-19 and after hospitalization the underling, not previously diagnosed idiopathic pulmonary fifi brosis was suspected in this patient. Due to COVID-19 infection and suspected idiopathic pulmonary fifi brosis the patient was administered Pirfenidon to treat the deep fifi brotic changes. The case was studied during the period from November 2020 – July 2021 in ”Vivamedi” hospital Tbilisi, Georgia. The systemic review was made using available literature from online libraries like PubMed, Google Scholar and UpToDate. The report was prepared after analysing all laboratory results and other radiological investigations that were performed during the course of treatment. The patient was treated mainly with Oxygen therapy, Pirfenidone and anticoagulants. The patient recovered from COVID-19 with minimal pulmonary fifi brotic changes. The vitals of the patient were stabilised and the lab results returned to normal. The patient was discharged from the hospital after 10 days and fully recovered from the viral infection. The survival after COVID-19 pneumonia in a patient with newly diagnosed IPF under antififi brotic + treatment without serious deterioration is a novel case. Antififi brotics which are available or developing not only have a role in treating such cases but can also be valuable in treating severe COVID-19 in patients without IPF, and might also be helpful preventing pulmonary fifi brosis after SARS-CoV-2 infection.
Copyright (c) 2022 Ketevan Tsanava, Lia Trapaidze, Elene Shengelia (Author) https://creativecommons.org/licenses/by-sa/4.0/
Plasma radiation treatment influence in the process of infected postoperative wounds
In the work have discribed methods of the treatment of purulent wounds by plasma rays during post-caesarean section sepsis in gynecological patients group. It was established that along with the basic treatment, the use of plasma rays as an auxiliary method relatively reduces the wound healing time in that group. Also, it was appealed on the simplicity and budget of the method as effective.
Copyright (c) 2022 Medea Daraselia, Sulkhan Jaiani, Eliza Mgaloblishvili, Bardi Tsutskiridze (Author) https://creativecommons.org/licenses/by-sa/4.0/
Dacriocistorhinostomy and Screening of the Recurrence
The relevance of the pathology of the lacrimal ducts to date remains extremely important, as it leads to disability and loss of professional fifi tness for a significant number of the working population. Complaints of lacrimation are presented by 6 to 25% of all patients who visit an ophthalmologist. Diseases of the lacrimal ducts are not only the cause of disability, but also lead to serious complications. Creeping corneal ulcer, leading to persistent visual impairment or even loss of vision, is associated with the presence of dacryocystitis in 40-50% of cases. Severe complications may also arise if purulent dacryocystitis remains unrecognized before surgery on the eyeball.
Copyright (c) 2022 Giorgi Petriashvili, Shorena Tsiklauri, Nato Nakudashvili, Mariam (Maka) Lomaia, Anna Akhalaia (Author) https://creativecommons.org/licenses/by-sa/4.0/
Clinical case of neutropenia, juvenile idiopathic arthritis in infant
Neutropenia is known to result from decreased production, ineffective granulopoiesis, shift of circulating polymorphonuclear cells (PMN) into the vascular endothelium or tissue pools, or increased peripheral destruction. Juvenile idiopathic arthritis (JIA) is a chronic idiopathic inflfl ammatory disease that predominantly affects the joints. The article presents a clinical case of a patient 13 month old. The condition was evaluated as JIA, and glucocorticosteroid therapy was with high doses of intra venous. There was no exacerbation of the disease.
Copyright (c) 2022 Tinatin Kutubidze, Eka Naxucrishvili, Karaman Pagava (Author) https://creativecommons.org/licenses/by-sa/4.0/
Neurocognitive functions and some electrioencephalographic changes in preadolescent children with different degrees of primary hypothyroidism and mild iodine deficiency
Neurologic and electrophysiologic changes in children with mild hypothyreosis and euthyroid goiter at the background of mild ID are not well understood at present. Our goal was to evaluate of some cognitive disturbances and alteration of some EEG parameters in preadolescent children at early stages of the development of primary hypothyreosis and euthyroid goiter. 55 somatically healthy preadolescent children, aged 8-12 years with the 1st degree of diffuse goiter underwent clinical and neurological investigation of cognitive functions: ”copy”, ”time to copy” and ”recognition” using Rey Complex Figure Test and recognition trial as well as Rochester fatigue Diary test; Motor Fatigue index, PASAT – 3 (second version) and lassitude was evaluated. Digital 21 channeled EEG study was also performed. Study groups were randomized to: children with overt mild hypothyreosis; children with subclinical hypothyreosis; euthyroid children; healthy controls. Mediana of UIE 64 was in the lower 3rd in the range for mild ID. Children of the study group more often had non-specififi c neurologic symptoms. All indices of neurocognitive dysfunction were more frequent in patients with overt hypothyreosis (P<0,001) and in lesser extent were present in subclinical hypothyreosis and euthyroid goiter, compared to controls. This was accompanied by the changes of EEG parameters. The pathologic visual version of EEG had 90% of children with overt hypothyreosis. In turned out that in prepubertal children is accompanied by cognitive disorders represented by Mild Cognitive Impairment; among neurologic subclinical signs of manifestation of ID the Fatigue test is of great sensitivity; even mild ID is characterized by specififi c changes of the frequency and amplitude of physiologic spectrum of EEG activity, mainly of aA; pathologic consequences of ID are manifested both in overt and subclinical hypothyroidism and in lesser extent in patients with euthyroid goiter.
Copyright (c) 2022 Nato Natroshvili, Nunu Beridze (Author) https://creativecommons.org/licenses/by-sa/4.0/
Modern aspects of chronic rhinosinusitis treatment
In this work, we discuss the development of a new method of immunogenesis and treatment of infectious and infectious-allergic chronic sinusitis and its effectivness, based on new targeted methods of immunocorrection, taking into account the severity of the inflfl ammatory process, current complaints and duration. 52 patients were under observation. The results of treatment with an aerosol of recombinant interferon αа-2Ь (in the form of Gripferon drops) in different types of chronic rhinosinusitis were studied. It has been shown that aerosol therapy with Gripferon gives promising results – subjective condition of patients and rhinoscopic and endoscopic data, as well as improvement of nasal olfactory function and regulation of mucociliary clearance, which indicates the effectiveness of this method of treatment.
Copyright (c) 2022 Mariam(Maka) Lomaia, Shorena Tsiklauri, Tamar Khechinashvili, Marina Tsabadze, Nato Nakudashvili (Author) https://creativecommons.org/licenses/by-sa/4.0/
Application of computational fluid dynamics (CFD) and fluid-structure interaction (FSI)in biofluids simulation to solve actual surgery tasks
Computational fluid dynamics (CFD) is a dynamically developing tool in mechanical engineering and interdisciplinary research. Medicine is one of the areas, where the application of current computational methods is extremely necessary. This study presents the results of using computational fluid dynamics methods to solve actual problems of surgery (modeling of blood flow in the patient-specific aorta of a child with congenital heart disease during bypass surgery; modeling of the flow of bile in the biliary system to predict cholecystectomy outcome; modeling of the chime flow in the colon). Simulation of blood flow in the aorta during shunting. Cardiovascular diseases are most common in the population and cause the prevailing part of premature mortality and disability in both adults and children. Blalock-Taussig shunting is mainly used to eliminate pathological changes in children. However, this procedure is carried out empirically: surgeons use their own experience. FSI enabled to numerically evaluate the shunt parameters and its location for proper lung development in children with congenital heart disease after shunt installation. Biomechanical analysis of the bile flow in healthy state, pathology, and after cholecystectomy. Cholecystectomy (removal of the surgical gallbladder) is usually taken to treat patients suffering from gallbladder disease and gallbladder pain. However, it should be noted that the results of the operation are not always successful. The biomechanical patient-specific model was created to assess the cholecystectomy outcome. Study of the chyme flow features in the colon. The large intestine is a long hollow muscle tube of complex shape, which digests and absorbs nutrients and water from food (which is commonly called chyme in medicine). The goal is to create a patient-specific model of the chyme and feces flow in the colon in the healthy state and pathology. Clinical applications of this model can be expressed in the description and understanding of the causes of the disorders as well as drug efficiency assessment to reduce the number of patients.
Copyright (c) 2022 Alex Kuchumov (Author) https://creativecommons.org/licenses/by-sa/4.0/
Methodological property for study of resistive arteries resistance as diagnostic method in arterial hypertension
The article draws on resistive vessels (vessels of resistance), which include precapillary (small arteries, arterioles, precapillary sphincters) and postcapillary (venules and small veins) vessels. The article discusses a new non-invasive method for studying resistive arteries. The article considers their diagnostic role in arterial hypertension.
Copyright (c) 2022 Brun Jean Frederic, Tamar Urdulashvili, Tamar Sanikidze, Marina Tsimakuridze, Maia Mantskava, Nana Momtselidze (Author) https://creativecommons.org/licenses/by-sa/4.0/
Rheological parameters as prognostic factors in blood loss
The aim of the work was to study the rheological status in experimental blood loss of varying severity. The experiments were carried out on out bred male rats. Depending on the severity of blood loss, the animals were divided into subgroups. In each subgroup, the erythrocyte aggregation index, erythrocyte membrane deformability index, and blood plasma viscosity were measured. As a result of statistical data processing, it was found that in case of blood loss of any severity, erythrocyte aggregation plays a leading role, followed by the blood viscosity parameter, and changes in membrane deformability are significant only in the decompensatory phase. Thus, it is once again emphasized that with blood loss, the presence of a persistent, starting from the first stage, changes in the rheological status, which mainly depends on the profile of erythrocyte aggregation. These experimental data, coupled with changes in the viscosity and membrane deformability of erythrocytes in the later stages of blood loss, lead to the idea of a careful use of the mass of erythrocytes for the treatment of critical conditions caused by blood loss. Continuation of experimental studies and translation of their findings into clinical medicine will most likely improve treatment tactics and increase its effectiveness in the treatment of patients with hemorrhagic shock.
Copyright (c) 2022 Vladimir Pisarev, Maia Mantskava, Nana Momtselidze, Giorgi Kuchava, Tamar Sanikidze, Marina Tsimakuridze (Author) https://creativecommons.org/licenses/by-sa/4.0/
New fundamental clinical approach to Pulmonary hypertension
Pulmonary hypertension (PH) is a group of diseases characterized by a progressive increase in pulmonary vascular resistance. Increased pulmonary resistance causes right ventricular heart failure and premature death of patients. The prevalence of pulmonary hypertension in the general population can be as high as 20-50 per 100,000 populations. Idiopathic pulmonary hypertension develops in young women between the ages of 20 and 40. In men, this disease is less common. Secondary PH develops in various chronic lung diseases and diseases accompanied by hypoxemia, as well as in the pathology of the left heart, chronic pulmonary embolism and other pathological processes accompanied by a violation in the pulmonary vascular bed. In recent years, considerable attention has been paid to the study of this issue, and the problem of timely and effective diagnosis and treatment of pulmonary hypertension is very relevant. It is necessary to highlight the following areas in order for the diagnosis, treatment and prevention of pulmonary hypertension to be successful. In the article we will analyze what is Definition Pulmonary hypertension.
Copyright (c) 2022 Viktoria Lishnevska (Author) https://creativecommons.org/licenses/by-sa/4.0/
The dimensionalization of schizophrenia(overview)
This article shows some different fundamental and practical approaches in modern psychiatry. Still, the understanding of the real nature of schizophrenia remains obscure. Limitations of approaches to conceptualizing and classifying schizophrenia based on a priori assumptions and expert consensus led to new efforts to classify schizophrenia quantitatively. This article is devoted to these and other issues.
categorical-dimensional model of schizophrenia
Copyright (c) 2022 Nino Dzagania, Nino Okribelashvili (Author) https://creativecommons.org/licenses/by-sa/4.0/
Participation of Vitamin Din Menopause Management Strategies
The health of the population is one of the key factors in economic development and, at the same time, an objective indicator of the quality of life. Public health policy in the world follows the path of large-scale financing of healthy lifestyle projects. The health of women was very relevant, because in a viewpoint of material and technical progress, an equal role has been assigned to men and women. Menopause and the climacteric state of women is a special issue in the health care of any prosperous European country. It is very important to approach the issue on a large scale, but this requires regional studies. Our interest fell on women with menopause living in Kvemo Kartli. In order to review and further transform the data for the Kvemo Kartli region of Georgia, we analyzed the literature on the advisability of using vitamin D as a factor that improves the quality of life of women in the menopausal period. We searched for peer-reviewed new and recent publications in order to write this review. A wide range of biological properties of vitamin D, which is involved in the regulation of many important physiological functions, is described here. The negative impact of vitamin D deficiency not only on the development of cancer, cardiovascular diseases, but also on the increase in the severity of climacteric syndrome is represented. The multiple beneficial effects of vitamin D have led to a detailed planning of the studies that the research team will carry out the next 12 months.
Copyright (c) 2022 Manoni Panchulidze, Rusudan Kvantchakhadze (Author) https://creativecommons.org/licenses/by-sa/4.0/
Computed tomography guided percutaneous transdiscal splanchnic nerve block for cancer pain treatment. Case report
Two cases of percutaneous transdiscal splanchnic nerve block for cancer pain treatment presented. Case 1. 50 years old man with pancreatic head and trunk cancer T4N1M0. Patients condition: intractable pain in upper abdomen during last two weeks, dysphagia, weight loss. Cholecysto-entero, gastro-entero and entero- entero anastomoses performed under epidural+general anesthesia. During 7 postoperative days pain relieved by continuous epidural anesthesia (0.2% ropivacain 5ml/hour). On postoperative day 8 epidural catheter removed due to dis lodgement. Morphine sulphate 10 mg iv injections with 4 hour intervals and cox- 2 pathway inhibitors was not sufficient for pain relief (pain score – 6-8 VAS). Splanchnic neurolysis performed on postoperative day 14. Patient laid in prone position on the computed tomography table. After marking of injection sites, definition of needles traces and deep local infiltration with 1% lidocain, two 22 gauge 20 cm Chiba needles had been inserted transdiscally on the level of T12/ L1. Pain relieved after injection of 4 ml 2% lidocaine on each side10 ml 10% aqueous phenol had been injected on each side for neurolytic block 0.1 g cefazolin injected intradiscally Patient had complete pain relief until day 5, when he felt severe continuous pain on his upper right abdomen. After two weeks of follow-up incomplete right splanchnic block diagnosed and to perform of repeated right side splanchnic neurolysis had been decided. On day 14 after 1-st neurolysis, a 3½ inch 25 gauge Quincke needle had been inserted in right retrocrural space on the level of L1. After contrast and 4ml 2% lidocaine injection, 15 ml 95% alcohol injected Pain relieved completely. No additional analgesia requirements lifetime (10 weeks). Case 2. 62 years old male with gastric cancer. Cancer recurrence after partial gastrectomy and severe intractable abdominal pain. 120 mg morphine hydrochloride daily, pain score 6-8 VAS. T12-L1 computed tomography guided transdiscal splanchnic nerve block performed in patient prone position. After marking of injection site at left side from vertebral column and deep infiltration with 1% lidocaine, a 22G 20 cm Chiba needle had been inserted. 0.1g cefazolin injected intradiscally. Intervertebral disk penetrated centrally and contrast spread was equal on both sides between aorta and L1 vertebra. Pain relieved after injection of 5 ml 2% lidocaine and 15 ml 95% alcohol. After procedure pain score – 3-4, patient was needed in 10 mg morphine hydrochloride and 150 mg lyrica daily. Computed tomography guided transdiscal splanchnic neurolysis is a safe and effective treatment tool for upper abdomen cancer pain relief. In cases of incomplete neurolysis repeated neurolytic block may be helpful.
Copyright (c) 2022 Vakhtang Shoshiashvili, Nino Japharidze, Inga Shoshiashvili, Tamar Rukhadze (Author) https://creativecommons.org/licenses/by-sa/4.0/