EEG study to HPT in patients with NS pathology using EEG database “EEGHUB.GE”

Abstract

Nowadays Hyperventilation is a provocation tool used during the electroencephalogram(EEG) registration to detect epileptiform activity. Even in cases where there are no typical manifestations on EEG during hyperventilation, the analysis of the shows a variety of responses, changes, and combinations. EEG data of patients from “EEGHUB.GE” was used. Big Data EEG collected in Georgia have been and integrated and uploaded to the European Open Science Cloud (EOSC). The aim of study is determined the pattern to hyperventilation based on time of onset EEG and age of patients 2186 patients, 1139 females and 1047 males aged 3 to 51years was studded. In 1201 patients EEG reaction/ response to hyperventilation was within the normal while those with pathological EEG reaction to hyperventilation (PERH) were 985. The patients were split into the following age groups: 3-6, 7-12, 13-18, 19-30, 31-50. Pathological EEG responses revealed of 3 types. During ongoing/current study pathological EEG-reactions to hyperventilation (I, II, and III) has been classified according to two parameters: time of manifestation (first, second, and third minutes) and age (3-6, 7-12, 13-18, 19-30, 31-50, 51and above) of the patient. The results have shown three types of pathological reactions of EEG and detected the time of manifestation – at the first, second and third minutes of hyperventilation: I type reaction on EEG 74.2% p<0001; II type reaction in 22.6% and III type reaction in the first minute – in 3.2% patients. The data of patients are valid by age and  type of reaction due to the first type of reaction prevailed in all age categories p<0,002, χ2(10)x(10)2=28.2. The distribution of patients by pathological reaction to Hyperventilation by age: EEG to hyperventilation revealed in 853 patients (86.6%) p <0.0001; χ2(2)=689,791 in the first minute. in in 95 patients (9.6%) p<0.0001 at the second minutes. The prevailed type I reaction on EEG in 64, 2%. II type reaction was in 29. 4%. III type reaction 6.3% patients Types EEG Reaction to Hyperventilation concerning age is not reliable to third minute of Hyperventilation. Three types of EEG reaction to hyperventilation were revealed in all age-groups of patients with various CNS dysfunctions: In all age groups the disorganization of basic EEG rhythm in the first, second and third minutes of hyperventilation. In the first minute of hyperventilation between all types of EEG reaction and age (3-6, 7-12, 13-18, 19-30, 31-50) a significant ratio was revealed, which was not observed in the second and third minutes. EEG-response to hyperventilation based on ages of patients should be taken account for scientific and clinical study.