Vasopressin improves the production of a conditioned two-way escape reflex

Abstract

Vasopressin (Lvp) is neuropeptide produced largely in the hypothalamus. Lvp is asopressin (Lvp) is neuropeptide produced largely in the hypothalamus. Lvp is released from paraventricular nucleus (PVN) and supraoptic nucleus (SON) mag- eleased from paraventricular nucleus (PVN) and supraoptic nucleus (SON) magnocellular terminals located in the neurohypophysis [1] ocellular terminals located in the neurohypophysis [1]. Upon entering the systemic pon entering the systemic blood supply, they exert endocrine actions including uterine contraction and milk lood supply, they exert endocrine actions including uterine contraction and milk ejection. Furthermore, Lvp released from terminals of parvocellular neurons of the jection. Furthermore, Lvp released from terminals of parvocellular neurons of the PVN influences adrenocorticotropic hormone synthesis and release from the adeno- uences adrenocorticotropic hormone synthesis and release from the adenohypophysis and, thus, modulates corticosteroid hormone levels and stress response ypophysis and, thus, modulates corticosteroid hormone levels and stress response [2,3,4]. The neurohypophyseal peptide Lvp play an important role in the regulation 2,3,4]. The neurohypophyseal peptide Lvp play an important role in the regulation of such processes as learning and memory. The participation of these peptide in the f such processes as learning and memory. The participation of these peptide in the processes of memory and learning have been con rocesses of memory and learning have been confi rmed by investigations in which rmed by investigations in which neurohyphopiseal extract has been employed [5,6]. It is yet unclear exactly what eurohyphopiseal extract has been employed [5,6]. It is yet unclear exactly what role vasopressin has in the organization, development, and replication of long-term ole vasopressin has in the organization, development, and replication of long-term memory traces. We investigated the effect of modest dosages of vasopressin on emory traces. We investigated the effect of modest dosages of vasopressin on the rate of conditional bilateral escape re he rate of conditional bilateral escape refl ex elaboration in rats weighing 250-300 g ex elaboration in rats weighing 250-300 g for this purpose. The experiment consisted of two groups of animals: control and or this purpose. The experiment consisted of two groups of animals: control and experimental. During 12 days, 15 minutes before testing, experimental animals were xperimental. During 12 days, 15 minutes before testing, experimental animals were given 4 g/0.2 ml lysine 8-vasopressin (Gedeon-Rixter) intraperitoneally. The equal quantity of saline was administered into the control animals. We employed the T uantity of saline was administered into the control animals. We employed the T Student criteria for statistical data analysis. It was shown that in experimental group tudent criteria for statistical data analysis. It was shown that in experimental group the indices of correct responses, as a latent period of reaction of active avoidance, he indices of correct responses, as a latent period of reaction of active avoidance, significantly lagged behind the control group. The level of conditional re cantly lagged behind the control group. The level of conditional refl ex on active defensive escape was checked during three days in two weeks, 1 month and ctive defensive escape was checked during three days in two weeks, 1 month and 2 months after such termination of experiment in both control and experimental months after such termination of experiment in both control and experimental groups of animals. However, through the roups of animals. However, through the fi rst and second month breaks, the level rst and second month breaks, the level of fulfillment of conditional re llment of conditional refl ex reaction at the experimental animals statistically ex reaction at the experimental animals statistically significantly (P <0,01) exceeded those of control group animals. Therefore, vaso- cantly (P <0,01) exceeded those of control group animals. Therefore, vasopressin promotes preservation of a trace of memory and had anti amnesic effect