Alteration of immune status during treatment with β-blockers in patients with essential hypertension

Abstract

The balance of cytokines (IL-2, IL-10, IF-γ) in patients with essential hypertension before and after treatment with β-blockers was studied. 20 patients aged 45-65 years and diagnosed with essential hypertension (12 women, 8 men) were investigated. For the treatment of hypertension, patients received second-generation beta-selective β-blockers Egilok and Betalok Zok, and third-generation β-blocker Nebilet for one month. Patients performed their blood pressure measurements daily in the morning during I month. The content of interleukins (IL-2, IL-10, IF-γ) in the blood by the immune enzymatic ELISA method on a semi-automatic reader Stat Fax 3200 with RayBio, (USA) reagent was measured. The results of our studies show an increase in the level of CD4+ (IL-2) cytokines in the blood of the studied hypertensive patients, which coincides with the literature data on the important role of CD4+ pro-inflfl ammatory cytokines in the pathogenesis of hypertension. After 1 month of treatment with β-blockers, the patient’s arterial pressure and IL-2 level content in the blood decreased. These data indicate the important role of inflfl ammation in the pathogenesis of hypertension and the anti-inflfl ammatory effects of β-brokers, used in the treatment of hypertension.