Comparative assessment of macro-,micro- and molecular rheological factors in patients with ischemic stroke. (Preliminary results)

Abstract

Currently, the main cause of death in the developed countries of the world are diseases of the circulatory system, including vascular diseases of the brain. The development and implementation of new programs and methods for diagnosing, treating and preventing cerebrovascular diseases is the most important medical, social and economic task. Prioritization of fundamental studies in the fifi elds of neurology and angiology has been the study of pathophysiological mechanisms of ischemic stroke development, as study of rheological properties. Our goal was to study a group of patients with ischemic brain stroke. Our group was from 10 people with an average age 72±5,4 years, the control group consisted of volunteers aged 69±2,3 years (n=12). All subjects underwent the following studies 1) To monitor acrorheological factors, we examined hematocrit and plasma viscosity. For this we used HumanCounter, Germany. 2) To monitor macrorheological factors, we studied the aggregability of erythrocytes and the deformability of erythrocyte membranes. For this we used the texture analysis method and the fifi ltration method. It turned out that in the group of patients with ischemic stroke, all parameters were changed, but the percentage of signifificant destruction was most observed in the direction of microrheological factors, more precisely, the aggregation of erythrocytes changed by more than 2 times compared to the control group. Our preliminary experiments have shown that erythrocyte aggregation is a necessary parameter for assessing blood rheology.